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crohns and heredity

by jennie
(canada)

hi would my daughter have crohns disease even though i don't have it but her father does




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crohns and heredity

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Jan 05, 2012
 crohns and heredity NEW
by: Lydia D.

Yes, you are most likely are a carrier of some of the 71 identified gene loci, which increase the risk of Crohn's disease.

Researchers estimate that there could be well over 300 different genome risk loci involved in determing the various Crohn's subtypes.

http://www.nature.com/nature/journal/v474/n7351/full/nature10209.html

http://www.genomeweb.com/sequencing/sequencing-gwas-loci-uncovers-rare-variants-independently-contribute-crohns-dise

If you have another (autoimmune) disease, for example: ulcerative colitis, coeliac disease, psoriasis, diabetes, lupus erythrematosus, rheumatoid arthritis, etc., this can also increase the risk of offspring developing Crohn's disease because of overlapping genome risk loci between diseases.

http://en.wikipedia.org/wiki/Crohn%27s_disease



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